Chicken Egg Yolk-IgY: Passive Immunization Promising Targeted Therapy of COVID-19 Pandemic

The world is threatened by the lethal effects of Coronaviruses (CoVs) that associated with major respiratory disorders. CoVs are large, enveloped, positive-stranded RNA and therefore, it considered a complicated virus structure. spike (S) protein exists in CoV’s structure regulates viral access to host using angiotensin-converting enzyme 2 (ACE2) receptor for both severe acute syndrome Coronaviruses-2 (SARS-CoV-2) and/or SARS-CoV initiates animal/human disease elevated immune responses. binding domain (RBD) S-proteins essential CoVs-gene sequences; however literature discussed CoV S-protein relation receptor-binding little. Therefore, finding natural antiviral limit spreading important. Herein, Immunoglobulin (Ig) Y kind passive immunizations, represents 60% egg-yolk can preventing many infectious diseases due particularities IgY-molecule shape functional bioactivity combat pathogens. Comparing IgY other Ig(s) antibodies, makes minimal animal stress, produces lowest responses mammalian factors. Besides, most cost-effective extraction precipitation which efficient protocol produce about (95% purity) antibodies. We reported has killing power bacterial infections broilers beneficial hygienic meat. Also, IgY-technology global application treatment cancers. Interestingly, anti-SARS CoV-2 single-chain fragments variable (scFv) IgY-antibodies separate from cell ACE2-and RBD-receptors. expressed scFv-antibody be assigned specific-antigen potential neutralization make better understanding host-cycle range SARS-CoV2 adapt ACE2 SARS-CoV-2 infection. we concluded this review promising therapeutic target novel disease-19 (COVID-19) pandemic.